Alpha2-macroglobulin is a very large size (725 kDa) protease inhibitor, primarily synthesised by hepatic parenchyma cells. It is involved in the inhibition of enzymes acting in the kinin-kallikrein, complement, coagulation and fibrinolytic systems. In addition to these inhibitor roles, alpha2-macroglobulin is used as a transporter for many small peptides (such as cytokines or growth factors), … Continued
The presence of protein in the urine is an indicator of various kidney diseases, including the progressive decline of the glomerulus. Kidney disease develops in 30-40% of insulin-dependent diabetics. The early detection of small quantities of albumin in the urine (concentrations of the order of 20 to 50 mg/L) enables early diagnosis of the disease, … Continued
Beta2-microglobin (ß2M) is a low molecular weight (11.8 kD) protein present on the surface of many cells. Beta2-microglobin exists in two forms: in free form or membrane form, identified as the light chain of the class I major histocompatibility complex (MHC). Despite its small size, allowing it to pass through the glomerular membrane, less than … Continued
The presence of protein in the urine is an indicator of various kidney diseases, including the progressive decline of the glomerulus. Kidney disease develops in 30-40% of insulin-dependent diabetics. The early detection of small quantities of albumin in the urine (concentrations of the order of 20 to 50 mg/L) enables early diagnosis of the disease, … Continued
Alpha1 microglobulin (α1-M), sometimes referred to as human complex forming protein (HC), is a small, low molecular weight (33kDa) globular glycoprotein. Its physiological concentration in urine is very low. It is one of the most constant microproteins present in urine in cases of tubular damage. It is filtered by the glomerulus and then reabsorbed almost … Continued
